High-Dose IV Vitamin C
The benefits of high-dose IV vitamin C for fatigue extend from its antioxidant, endothelial-restoring, anti-inflammatory, and immunomodulatory effects.

High-dose IV vitamin C has antioxidant, endothelial-restoring, anti-inflammatory, and immunomodulatory effects.
A 2021 review collected nine clinical studies on Vitamin C treatment in post-viral fatigue with similar markers as Long COVID fatigue, such as inflammation, oxidative stress, and circulatory disorders. There were four controlled trials, and in three of them, there was a significant decrease in fatigue scores between the vitamin C and control groups. The remaining five trials were observational studies, and four of these observed a significant reduction in pre-post fatigue levels.
Aphaeresis – EBOO /F
A patient being treated with the EBOO /F aphaeresis device. Dark, dirty blood comes out of one arm. The blood is filtered, removing any debris, and also infused with ozone by the device. Then the purified, bright red, blood is returned to the other arm.

A patient being treated with the EBOO /F aphaeresis device.
A 2022 study found that those with chronic fatigue syndrome due to viral or autoimmune pathogenesis, such as Long COVID fatigue, may be linked to receptor antibodies against ß- adrenergic and muscarinic receptors since both of these autoantibodies are elevated in those with Long COVID.
Aphaeresis uses a special filter that, based on current research, appears effective in reducing these antibodies, which then improves symptoms in those with Long COVID fatigue.
Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy (HBOT) is a promising treatment in which the patient is placed in a chamber where the atmospheric pressure is increased while they breathe in pure oxygen. This treatment helps patients with Long COVID intake more oxygen and deliver this oxygen more effectively to the cells and tissues of their body.

Dr. Milgrom observing a patient in one of our Sechrist H-Series Monoplace Hyperbaric Chambers.
A 2021 study on HBOT for Long COVID evaluated the effect of HBOT on ten patients, recording their fatigue scale. The results showed a significant improvement in fatigue, global cognition, executive function, attention, information profession, and verbal function.
Methylene Blue
Methylene Blue works wonders on CV19, Long COVID, Epstein Barr and Lyme disease patients. These diseases damage the mitochondria causing their Electron Transport Chain to stop working properly. Your mitochondria are no longer able to make ATP which is the primary energy source for important biological functions.

Methylene Blue donates electrons directly into ATP synthase.
Stopping the production of ATP causes the cell to essentially become senescent. It’s trying to live, it’s trying to die, it doesn’t know what to do, it doesn’t have the energy to do anything, so it just hangs around. Now imagine this happening to all 50 trillion or so cells in your body… Fatigue unlike anything you have ever experienced.
Methylene Blue Donates Electrons Directly into ATP Synthase
When Methylene Blue is put into the body and enters the cell, it bypasses the part of the Electron Transport Chain that has been damaged and donates electrons directly into ATP synthase at the end of Electron TransportChain.
Now the mitochondria can make ATP with a source of electrons that has not been cut off and the cell can now repair itself. This is what we believe is happening inside the body and the clinical results we are achieving with our patients reinforces this.
The point is that with Methylene Blue your body can repair itself, using the ATP produced by your own mitochondria, giving your own cells the energy they need to repair themselves.
Whole Body Cryotherapy
Whole body cryotherapy exposes a patient to extremely cold and dry air for two to three minutes. This provides benefits such as vasoconstriction, slower nerve condition, and stimulation of dermal thermo-receptors. It is currently used in inflammatory conditions such as Fibromyalgia, Rheumatoid Arthritis, and Ankylosing Spondylitis.

After a session, there is an increase in anti-inflammatory cytokines and a decrease in pro-inflammatory cytokines supporting anti-inflammatory response.
In January 2022, a hospital in Italy detailed a case report of cryotherapy for Long COVID on a 75-year-old patient. Immediately following his first session, he reported immediate improvements in breathing, and the following hours showed improvement in sleep quality and a reduction of weakness. From this point on, the patient reported lower fatigue.
FLCCC Protocols
While the above treatments are promising and beneficial for Long COVID fatigue, they also require treatment at a facility with the necessary equipment and can be fairly expensive. The FLCCC has released some protocols to follow, which allow those who suffer from Long COVID fatigue some guidance on how to treat their condition at home.
Supplementation
Supplements can help reduce inflammation or address deficiencies seen in those with Long COVID fatigue. Omega-3 fatty acids, vitamin D, curcumin, vitamin C, melatonin, kefir, and probiotic yogurt can all help reduce both mental and physical fatigue.
However, to see a benefit, the correct dosage should be taken. The FLCCC protocols include guidance on how much of each supplement to take.
Alternative Therapies
The FLCCC also suggests that behavioral modifications, psychological support, and mindfulness therapies can help improve your overall well-being and mental health.